2018 : Particle micronization of Curcuma mangga rhizomes ethanolic extract/biopolymer PVP using supercritical antisolvent process

Prof.Dr.Ir. Sugeng Winardi M.Eng
Dr.Eng. Siti Machmudah , ST.,M.Eng.


Abstract

Curcuma mangga (C. mangga) rhizomes ethanolic extract/PVP micronized particles were prepared using the supercritical antisolvent (SAS) method. The ethanolic extract was obtained from dried C. mangga rhizomes using soxhletation. A mixture of acetone and ethanol (90:10 (v/v)) was used as the solvent, while supercritical CO2 was used as the antisolvent. The effect of the operating conditions on the size and morphology, and characteristic of the particles was evaluated. By using this process, nanoparticles with an average diameter ranging from 111 ± 47 nm to 210 ± 120 nm were successfully formed. The particle size decreased as the temperature increased, whereas pressure did not significantly affect the particle size or morphology. A lower concentration of the feed produced smaller particle sizes. Based on the optimization using the RSM Box-Behnken design, the best result was predicted at a …